Advanced Multi-scale Growth Models
Biological materials often have several important scales, from the sub-cellular level (~10^-6 m) up to the human body (~1m). The continuum mechanics theory of finite growth represents cellular-level activity such as hypertrophy on a larger scale. There is much room for improvement, however, better modeling the behavior of morphogens and mechanical components in and between cells. We are working towards more mechanistic growth models that capture the nonlocal behavior of living tissues due to intracellular interactions.
This work is supported by the National Science Foundation's Computer and Information Science and Engineering Research Initiative.